Total Synthesis of Resveratrol-Based Natural Products:A Chemoselective Solution

摘要

The past decade has witnessed tremendous interest in the relatively small natural product resveratrol(1,Figure 1)primarily because of its promising and selective array of in vitro and in vivo activity against a collection of disease states,including inflammation,heart disease,aging,and cancer.In fact,its truly unique biochemical profile,coupled with its relatively high concentration in red wine(ca.100 mu M)and near absence in white varietals and grape juice,has led to the popularly held notion that resveratrol is the main protagonist for the so-called "French paradox".