Asymmetric Suzuki-Miyaura Coupling Reactions Catalyzed by Chiral Palladium Nanoparticles at Room Temperature

摘要

Recently,there has been great interest on the use of metal nanoparticles(NPs)for nanocatalysis.The catalytic properties of metal NPs depend on the particle size,which is controlled by the nature of the protective ligands(stabilizers;for example,thiol and phosphine).Although a number of thiol-stabilized metal NPs have been reported,metal NPs stabilized by bisphosphine ligands have received much less attention.Palladium NPs have become of increasing scientific interest as catalysts for carbon-carbon bond-forming reactions,such as Suzuki-Miyaura cross-coupling reactions,which are among the most powerful methods in organic synthesis.These reactions are typically performed under heating or at reflux.Much less is known about the room-temperature Suzuki-Miyaura cross-coupling reaction catalyzed by phosphine-stabilized Pd NPs.