Optical Analysis of Hg~(2+) Ions by Oligonucleotide-Gold-Nanoparticle Hybrids and DNA-Based Machines

摘要

Mercury ions act as severe environmental pollutants and they have serious medical effects.Specifically,microbial biome-thylation of mercuric ions (Hg~(2+)) yields methyl mercury that accumulates in the body through the food chain,and is known to cause brain damage and other chronic diseases.Also,it is important to control the leakage of Hg~(2+) ions from amalgam fillings in teeth during dental care.Hence,the rapid and sensitive analysis of Hg~(2+) ions in water or food resources is important,and the analysis of Hg~(2+) ions in human fluids,for example,saliva has considerable diagnostic value.Different procedures for the analysis of Hg~(2+) ions were developed,including electrochemical methods,optical methods that include Hg~(2+)-sensitive fluorophores or chromophores,and the use of proteins and functional polymer materials.