Kinetics of I minium Ion Catalysis

摘要

Since MacMillan's original report in 2000,iminium ion catalysis using cyclic secondary amines has been established as an effective platform for asymmetric Diels-Alder,conjugate addition,[3+2] cycloaddition,[4+3] cycload-dition,and conjugate reduction reactions,thereby providing powerful new methods for fundamental bond-construction processes.Such reactions frequently proceed in high yield and with exceptional levels of asymmetric induction,thus forming a new mode of reactivity that has met with overwhelming acceptance from the chemical community owing to the highly practical nature of the transformations.