Electrospray Ionization Mass Spectrometric Study on the Direct Organocatalytic alpha-Halogenation of Aldehydes

摘要

The mechanism of reactions in solution can be studied using electrospray ionization mass spectrometry (ESI-MS).We recently conducted an ESI-MS study on the aldol reaction catalyzed by L-proline where we were able not only to follow the reaction over time,but to isolate and characterize all the reaction intermediates by tandem mass spectrometry (MS/MS).