Mimicry of Polyketide Synthases-Enantioselective 1,4-Addition Reactions of Malonic Acid Half-Thioesters to Nitroolefins

摘要

Thioesters are versatile building blocks that allow for a wide range of subsequent transformations into,for example,amides,aldehydes,alpha-ketoalkynes,and ketones.A straightforward method for the introduction of thioesters is the addition of thioester enolates to electrophiles.In organic synthesis,thioester enolates are typically generated by reaction of the thioester with a metal-based Lewis acid.In contrast,nature does not rely on metal ions for the generation of thioester enolates.