Synthesis of Pentaantennary N-Glycans with Bisecting GlcNAc and Core Fucose

摘要

Recombinant therapeutic glycoproteins contain mainly asparagine-linked oligosaccharides (N-glycans), which are often essential for the proper function of the glycoprotein. The heterogeneity of the glycans in natural glycoproteins is a large obstacle for the entire research in the field of glycobiology,and despite recent advances in chemical synthesis of N-glycans, the majority of N-glycans for biological studies are still isolated from natural sources.