A Catalytic,Me_2Zn-Mediated,Enantioselective Reformatsky Reaction With Ketones

摘要

The Reformatsky reaction,one of the classic "named" reactions,was discovered almost 120 years ago and is still widely used in synthesis.It consists of the zinc-induced formation of p-hydroxyalkanoates from alpha-halocarbonyl compounds and aldehydes or ketones.Its excellent functional group tolerance and the possibility of preparing the reagent in situ,by activation of zinc metal following a variety of different methods,have contributed to its success.In the last six years,homogeneous Reformatsky-type reactions based on the use of Me_2Zn or Et_2Zn in the presence of nickel or rhodium have been described.