Inhibitors of HIV-1 Protease by Using In Situ Click Chemistry

摘要

The global AIDS epidemic has claimed the lives of more than 20 million people since 1981. Another 10 million are now living with HIV and most of these are likely to develop AIDS over the course of the next decade. In spite of the various treatment protocols available, including the mainstream highly active antiretroviral therapy (HAART), the number of people infected with HIV continues to rise. The most recent UNAIDS (United Nations Programme on HIV/AIDS)/world health organization estimates show that, in 2004 alone, 4.9 million people were newly infected with HIV.