Polyol Synthesis through Hydrocarbon Oxidation: De Novo Synthesis of l-Galactose

摘要

Direct oxidation of C-H bonds has the potential to emerge as a powerful approach for introducing oxygen and nitrogen functionality in the synthesis of complex molecules.[1] Functional- group manipulations (FGMs) that are required for carrying oxygenated functionalities throughout a synthetic route may be avoided by installing them directly into the hydrocarbon framework.[2] For a hydrocarbon oxidation strategy to reach its full potential, C-H-oxidation reactions with high levels of chemo-, regio- and stereoselectivity must be identified and developed.