High-Yield Synthesis of [2]Catetianes by Intramolecular Ming-Closing Metathesis

摘要

The development of effective approaches to interlocked molecular rings, catenaries, constitutes a great challenge in preparative chemistry, especially in light of their role in DNA structure and related molecules of biological relevance. Following thepioneering work of Schill and Wasserman, template-directed strategies that used transition metal complexa-tion, pi-donor-acceptor interactions, and hydrogen bonding have not only made the synthesis of interlocking rings more accessible but have also allowed the introduction of various functional groups. In most cases, the cyclization reaction is restricted to the formation of ether and amide bonds or quaternary ammonium salts by an intermolecular pathway.