Synthesis and a Preliminary DNA Binding Study of Hybrids of the Carbohydrate Domain of Calicheamicin γ_1~1 and the Aglycone of Daunorubicin: CaHchearubicins A and B

摘要

Many important medicinal agents of natural origin contain a sugar or sugurlike moiely. From a chemical standpoint, such agents can be dissected into aglycone and carbohydrate domains. In most instances, both components in themselves are totally lacking in useful biological activity. Traditionally, considerations about the mechanism of action of the drug have been directed to the aglycone. with the carbohydrate viewed as a necessary appendage for biotransport or for other factors related to drug availability.