A Near-Infrared-Fluorescence-Quenched Gold-Nanoparticle Imaging Probe for In Vivo Drug Screening and Protease Activity Determination

摘要

Nanoscale fluorescence optical imaging probes are paving the way for novel methods to sense and spot live molecular targets.Various probes have been developed,including semiconductor quantum dots,magnetofluorescent nano-particles,polymer conjugates,nanocomplexes,and gold nanoparticles (AuNPs).The application of conventional fluorescent probes is limited because they generally display only modest fluorescence changes,thus providing insufficient resolution.