Electrically Addressable Cell Immobilization Using Phenylboronic Acid Diazonium Salts

摘要

Recently there has been much interest in the development of cell arrays for such areas as drug screening, gene expression profiling, stem-cell differentiation, understanding higher-level organization of tissues and organisms, and other developing fields involving the functions of biological systems. Cell-based arrays have the potential to lead to a new generation of powerful sensing devices, as living cells contain specific biological and chemical receptors with processes that respond to minute concentrations of molecules. The ability to readily control the spatial organization and interactions between populations Of cells would also prove valuable for research involving cell-cell or host-pathogen interactions and cell signaling pathways.