Rh~I-Catalyzed Hydration of Organonitriles under Ambient Conditions

摘要

The hydration of organonitriles is a reaction of great synthetic significance for the preparation of organoamides(e.g.,acrylamide and nicotinamide)in view of its broad industrial and pharmacological applications.For example,hydration of acrylonitrile is used to produce more than 2X10~5 tons of acrylamide per year.Classically the reaction proceeds in a sequence of distinct steps upon treatment with strong inorganic acid or base,but these methods are frequently unable to control overhydrolysis.