Vanadium-Catalyzed Enantioselective Desymmetrization of meso Secondary Allylic Alcohols and Homoallylic Alcohols

摘要

Kinetic resolution of secondary allylic alcohols and homoallylic alcohols is one of the most important synthetic protocols used to provide enantiomerically enriched epoxides, especially those carrying several contiguous stereogenic centers. These chiral building blocks would be very useful for the asymmetric synthesis of natural products and biologically active substances. Many efficient protocols have been developed to satisfactorily mediate the kinetic resolution of allylic alcohols. Recently, we reported new bishydroxamic acid (BHA) ligands for the enantioselective vanadium-catalyzed asymmetric epoxidation and kinetic resolution of allylic alcohols and homoallylic alcohols (Scheme 1).