Catalytic Enantioselective Michael Addition of 1-Fluoro- bis(phenylsulfonyl)methane to α,β-Unsaturated Ketones Catalyzed by Cinchona Alkaloids

摘要

There is a high demand in both academia and industry for enantiopure fluorine-containing organic molecules because of their unique pharmacological properties. Although their occurrence in natural systems is rare, monofluorinated analogues of biologically active compounds are often evaluated as bioisosteres of the parent molecules. Compounds with monofluoromethyl groups are also important in biological systems.