Synthesis of Marine Alkaloids from the Oroidin Family

摘要

rolyheterocyclic, nitrogen-rich alkaloids probably rank among the most challenging synthetic targets in organic synthesis. In this regard the oroidin class of alkaloids has received much attention recently (Scheme 1), among them sceptrin (1), the axinellamines (2 and 3), palau' amine (4), and ageliferin (5). These marine natural products arise from one precursor, the rather inconspicuous pyrrolo-imidazole alkene oroidin (6) first identified in 1971.