Total Synthesis of(±)-Axinellamines A and B

摘要

The axinellamines(1,2,Figure 1)isolated by Quinn and coworkers in 1999,are among the most complex marine natural products isolated to date.The intricate architecture of these molecules includes a tetracyclic bisguanidine core with eight contiguous stereocenters.The highly polar nature of the two guanidine units present in 1 and 2 further complicate the practical aspects of dealing with such molecules.