Mild Cobalt-Catalyzed Hydrocyanation of Olefins with Tosyl Cyanide

摘要

The diverse transformations in which nitriles participate (for example,RCN->RCO2H,RCONH2,RCHO,RCH2NH2,and RCN4,as well as Pinner and Ritter reactions) place them among the most versatile intermediates in organic chemistry.Although the displacement reactions of leaving groups by cyanide constitute the most common access routes to these,direct olefin hydrocyanation is an attractive alternative.In our continuing interest in the development of functionalization reactions of olefins,we have discovered a hydrocyanation reaction that is conceptually different from the existing methods that are available.