A Remarkably Efficient Fluoroalkylation of Cyclic Sulfates and Sulfamidates with PhSO_2CF_2H: Facile Entry into beta-Difluoromethylated or beta-Difluoromethylenated Alcohols and Amines

摘要

Fluorine is increasingly recognized as a remarkable element in the life sciences,based on the fact that incorporation of one or a few fluorine atoms in an organic molecule can often dramatically alter its stability,lipophilicity,bioavailability,and biopotency.Currently,"as many as 30-40% of agro-chemicals and 20% of pharmaceuticals on the market are estimated to contain fluorine".Fluorination and fluoroalkylation are the two major synthetic methods to introduce fluorine atoms or fluorine-containing moieties into organic molecules.