Development and Biological Assessment of Fully Water-Soluble Helical Aromatic Amide Foldamers

摘要

Much effort is being devoted to develop oligomers that adopt stable helical conformations and mimic the structures of folded biopolymers.For example,bio-inspired helical oligomers based on aliphatic backbones such as beta-pepti-des and peptoids may adopt helical conformations related to peptide a helices and polyproline type I helices,respectively.