Specific Fluorescent Probe for 8-Oxoguanosine

摘要

DNA in living organisms suffers from oxidative damage by reactive oxygen species to form a variety of oxidized nucleosides.8-Oxoguanosine (8-oxoG) is a representative metabolite derived by the oxidation of guanosine (G;Scheme 1),and is known to induce G:C to T:A transversion mutations in DNA (C:cytidine;T:thymidine;A:adenosine).The 8-oxoG level is regarded as an index of oxidative damage of cells and is believed to have relevance to some diseases and aging.