Ultrafine Hydrogel Nanoparticles: Synthetic Approach and Therapeutic Application in Living Cells

摘要

The entry of drug payloads into the circulatory system is met by rapid removal by resident macrophages. The almost immediate drop in circulating levels of the therapeutic agent has been identified as a major obstacle for efficient drug delivery. Various physical properties determine the fate of NP-based (NP=nanoparticle) drug-delivery platforms in vivo. Size, surface charge, and surface hydrophobicity of the particles all affect the ability of macrophages to remove them from circulation and, hence, their bioavailability. Large particles (>200 nm diameter) are more easily captured by macrophages.