Models of Oxovanadium(IV)-Protein Interactions: The First Oxovanadium(IV) Complexes with Dipeptides

摘要

Vanadium is a trace element that produces significant physiological effects; for example, vanadate inhibits ion transport ATP-ases, phosphotyrosine phosphatase etc. Arguably, the most important physiological effect is the stimulation of glucose uptakeand glucose metabolism, that is, the insulin-like properties of both vanadate and oxovanadium(IV) species. The efficacy and relative lack of toxicity of oxovanadium(IV) derivatives in animal models of diabetes makes them a potential oral therapy in human diabetes in general, and in those forms of the disease that are resistant to insulin in particular. The mode of action of oxovanadium(IV) species is still not understood. Cornman and co-workers have suggested that a possible mechanism of V~(IV)O~(2+)action is the inhibition of protein tyrosine phos-phatases (PTPascs) by binding thiolate sulfur to V~(IV)O~(2+). In addition. Sapert