Modular Synthesis of Ruthenium-Labeled Diaryl Ether Peptoids

摘要

Research on peptide-like ("peptoid") compounds is of basic relevance to bioorganic and bioinorganic chemistry. Important examples include the fascinating β- and γ-peptides. Radioactive peptide metal complexes constitute a special case, promising the sensitive, selective detection or perhaps even the destruction of tumor cells; the biochemical selectivity is efficiently combined with high-energy radiation. The most prominent example used in nuclear medicine is luIn radio-labeled octreotide which binds to receptors of the regulatoiy hormone somatostatin. Beck et al. have reviewed the transition-metal complexes of amino acids and peptides as an emerging area of bioorganometallic chemistry.