Two Birds with One Metallic Stone:Single-Pot Catalysis of Fundamentally Different Transformations

摘要

Advances in metal catalysis have revolutionized organic synthesis,with the scope of metal-catalyzed reactions now covering nearly all areas of carbon-carbon,carbon-hydrogen,and carbon-heteroatom bond formation.For years,the goal was to develop catalysts that were highly selective for a single transformation.However,a promising current area of research is the use of a single catalyst to mediate more than one transformation in a selective manner.Whereas much early work was focused on using a catalyst for several similar transformations,recent investigations have shown that it is also possible to employ a single catalyst for several very different transformations in a single reaction sequence.This Minireview focuses on methods in which the mechanisms of the transformations are fundamentally very different.