Dimeric Aminoglycosides as Antibiotics

摘要

Aminoglycosides are an important class of natural products with antimicrobial activity against Gram-positive and Gram-negative bacteria. They have important clinical applications in cases of opportunistic infections accompanying AIDS, cystic fibrosis, and cancer. They are primarily used against infections caused by Gram-negative bacteria, particularly Pseudomonas aeruginosa, which are the leading cause of morbidity and mortality in patients having cystic fibrosis (CF). However, the rapid emergence of aminoglycoside-resistant bacterial strains is limiting their efficacy and making the discovery of structurally novel and more potent classes of semisynthetic antibiotics a pressing necessity.