Stepwise Solid-Phase Synthesis of Di- and Trinuclear Metal Complexes

摘要

Monodisperse oligomers play a central role in understanding the chemistry and the physics of polymeric organic and inorganic materials. The synthesis of monodisperse oligomers can be achieved by self-organization processes, random synthesis followed by separation processes, or by a step-by-step synthesis. All these strategies present their own advantages and disadvantages. Full control over chain length, end groups, and building-block sequence can be achieved using a stepwise approach. While this strategy is conceptually straightforward, it becomes increasingly tedious for higher oligomers owing to the purification steps needed. A particular elegant method for a repeated stepwise synthesis is the solid-phase synthesis methodology which allows the purification of all intermediates by simple filtration. This strategy has been successfully applied to the synthesis of organic oligomeric compounds while organometallic oligonuclear complexes have not been prepared in a stepwise manner by solid-phase synthesis. Mononuclear metal complexes have been prepared by solid-phase synthesis for example, for biolabeling purposes or oligonucleotide-DNA/RNA binding studies and a dinuclear complex has been synthesized by simultaneous double metalation of a peptide bound to a solid phase.