A Fluorescent Pyrophosphate Sensor with High Selectivity over ATP in Water

摘要

Recently,considerable attention-has been focused on the design of receptors and sensors that have the ability to bind and sense biologically important anions selectively through electrochemical and optical responses.Anions such as pyrophosphate (P_2O_7~(4-),PPi) and adenosine triphosphate (ATP) play an important role in energy transduction in organisms and control metabolic processes by participation in enzymatic reactions.ATP hydrolysis with the concomitant release of PPi is central to many biochemical reactions,such as DNA polymerization and the synthesis of cyclic adenosine monophosphate (AMP) catalyzed by DNA polymerase and adenylate cyclase,respectively.