Materials Research Laboratory, University of California, Santa Barbara, CA 93106, USA

摘要

Polyene macrolide antibiotics have found widespread use as antifungal agents. The family of polyene macrolides incorporating a mycosamine sugar represent the most common and widely used members of the class of natural products, and include amphotericin B, nystatin, candidin, pimaricin, and rimocidin. These stereochemically complex, highly oxygenated structures have attracted the attention of synthetic chemists. Amphotericin B was synthesized by Nicolaou and co-workers, and the aglycone of amphotericin B, amphoteronolide B, was prepared by Masamune and co-workers. We have been interested in the synthesis of polyene macrolides, but most of our work has focused on the oxopolyene subclass. We report herein the first synthesis of the rimocidin aglycone, rimocidinolide methyl ester (2).