An Organometallic Chemosensor for the Sequence-Selective Detection of Histidine- and Methionine-Containing Peptides in Water at Neutral pH

摘要

A synthetic receptor,which is bound through noncovalent interactions to an indicator,can function as a chemosensor.The fundamental requirement is that the displacement of the indicator by an analyte results in a change in its optical properties.An indicator-displacement assay (IDA) of this kind has been used to detect analytes such as citrate,tartrate,gallic acid,heparin,phosphates,carbonate,and amino acids.Relative to "classical" chemosensors with integrated binding and signaling components,IDAs have two major advantages:1) they are easy to generate because the signaling unit is attached by noncovalent interactions,and 2) the physical properties of the indicator (color,affinity for the host,solubility) as well as the indicator-receptor ratio can be varied according to specific needs.