Synthetic Strategy toward Skeletal Diversity via Solid-Supported, Otherwise Unstable Reactive Intermediates

摘要

Herein we report a new diversity-oriented synthetic pathway to skeletally diverse alkaloid-like compounds from simple, readily available starting materials. The synthetic strategy involves the generation and isolation of reactive, otherwise unstable dihydropyridines and dihydroisoquinolines on a solid support. A variety of reactions can be performed with the enamine double bond present in the isolated reactive intermediates, thus leading to skeletally diverse alkaloid-like products.