Highly Efficient Peptide Bond Formation to Functionalized Wells-Dawson-Type Polyoxotungstates

摘要

Polyoxometalates (POMs) are a large family of metal-oxygen clusters of the early transition metals in high oxidation states, most commonly V~V, Mo~(VI), and W~(VI). Their diversity in structure and composition allows a wide versatility in terms of shape, polarity, redox potentials, surface charge distribution, and acidity. The last twenty years have witnessed a growing interest in the biological properties of POMs and their potential applications in medicine. POMs exhibit antiviral-notably anti HIV-as well as antitumor and antibiotic activities. Nonetheless, progress along these lines has been quite slow because of the low physiological stability of most POMs. Only a few POMs were reported with enhanced hydrolytic stability. An original approach is the encapsulation of POMs in starch nanoparticles.