Breaking the Symmetry of Axially Chiral N-Aryl-2(1H)-pyriidinones by Spontaneous Crystallization

摘要

The atropisomerism of biaryl molecules has been studied extensively from both theoretical and synthetic perspectives. When rotation about the pivotal 1,1'-bond is slowed, these molecules can be resolved as optically active enantiomers. Many axially chiral biaryls such as BINAP (1,1'-binaphthalene-2,2'-diyl)bisdiphenylphosphane) or BINOL (2,2'-dihydroxy-1,1'-biphenyl) serve as ligands in transition-metal complexes used in catalytic asymmetric synthesis.