Pd-Catalyzed Nucleophilic Alkylation of Aliphatic Aldehydes with Allyl Alcohols: Allyl, 2-Tetrahydrofuryl, and 2-Tetrahydropyranyl Ethers as Useful C_3, C_4, and C_5 Sources

摘要

The allylation of aldehydes at both the carbonyl carbon atom and at the carbon atom α to the carbonyl group is among the most fundamental and useful methods for elaborating molecules. These reactions, in general, have been performed by using the activated forms of allyl alcohols, such as carboxylic acid esters and other organic and inorganic acid esters. A possible reason why allyl halides have been used most widely for alkylation is because of their ready conversion into a variety of allylmetallic species (Metal = Mg, Li, Si, Sn, etc.).