Highly Diastereoselective Conjugate Addition to Alkylidene Bis(Sulfoxides):Asymmetric Synthesis of (+)-erythro-Roccellic Acid

摘要

The conjugate addition of a nucleophile to an electron-deficient olefin is a key transformation for the synthesis of highly functionalized molecules.Facial control relying on an appended chiral auxiliary as an electron-withdrawing moiety has been extensively studied,and,despite recent advances in catalytic asymmetric processes,this strategy still has important advantages such as predictability and generality.