NMR-Guided Fragment-Based Approach for the Design of tRNA~(Lys3) Ligands

摘要

RNA is a key player in many cellular processes and in viral infection,and is therefore an attractive target in drug discovery.The clinical utility of antibiotic drugs that target the bacterial ribosome has demonstrated that RNA can indeed be a relevant target.Among other druggable RNA targets,functional sites within the genomic RNA of HIV-1,such as the transactivation-responsive element (TAR),the Rev-responsive element (RRE),or the dimerization-initia-tion site,have been selected as possible targets for new antiviral strategies.