Organocatalytic Asymmetric alpha-Selenenylation of Aldehydes

摘要

Asymmetric organocatalysis has become a field of central importance for the stereoselective preparation of chiral,enantioenriched molecules.In particular,chiral secondary amine catalysis has proven to be a powerful procedure for the enantioselective transformation of carbonyl compounds.Aminocatalysis has enabled the asymmetric alpha-,beta-,and gamma-functionalization of aldehydes and ketones with a wide range of electrophiles and nucleophiles by exploiting catalytic enamine SOMO (singly occupied molecular orbital),iminium ion,and dienamine activation modes (Scheme 1).