Catalytic Asymmetric Synthesis of Tertiary Alkyl Chlorides

摘要

The bioactivity and the synthetic utility of enantioenriched alkyl halides provide a strong impetus for the development of stereoselective methods for their synthesis.In recent years,a number of reports have described remarkable progress in the discovery of catalytic asymmetric approaches to this family of compounds (particularly,alpha-halocarbohyls]);nearly all of these processes generate secondary alkyl halides.