Rhodium-Catalyzed Enantioselective Conjugate Silyl Transfer: 1,4-Addition of Silyl Boronic Esters to Cyclic Enones and Lactones

摘要

Silicon connected to a stereogenic carbon atom is an important functional group in asymmetric synthesis. The synthetic equivalence of silicon and oxygen, which is achieved by the stereospecific oxidative degradation of a CSi bond,[1] as well as several stereoselective CC bond-forming reactions involving -chiral silanes[2] underscore the synthetic potential of silicon. Conversely, the number of effective methods for the direct enantioselective formation of CSi bonds is limited[3] and, therefore, novel asymmetric transition-metal-catalyzed reactions will certainly plug a synthetic hole.