Toward the Total Synthesis of Spirastrellolide A.Part 2:Conquest of the Northern Hemisphere

摘要

The novel antimitotic agent spirastrellolide A (1),isolated from the Caribbean sponge Spirastrella coccinea,is endowed with potent and selective phosphatase inhibitory properties.Although the relative stereochemistry of each individual domain embedded into the macrocyclic frame of this marine natural product has been elucidated by spectroscopic means,the relationship between these stereoclusters remains elusive and the absolute configuration of 1 is equally unknown.Scheme 1 therefore depicts only one of 16 possible isomers that might represent the correct stereostructure of spirastrellolide A.