Heteroditopic Rebek's Imide Directs the Reactivity of Homoditopic Olefins within Desolvated Quaternary Assemblies in the Solid State

摘要

Molecules with two different binding sites are important constructs in supramolecular chemistry.[1] Such heteroditopic molecules are designed, a priori, to assemble two different molecules and/or ions within ternary complexes, a process which is exploitable in areas such as separations,[2] nucleobase recognition,[3] and replication.[4] Whereas recent studies involving heteroditopic molecules have focused largely on the binding of ion pairs[2], [5] and the programmed assembly of metallosupramolecular architectures,[6] the application of heteroditopic molecules as artificial enzymes[7] that direct the formation of covalent bonds[8] remains a worthy goal. Indeed, since the work of Kelly et al. that described a heteroditopic molecule that employed hydrogen bonds to orient two different molecules in solution for an SN2 reaction,[9] advances have been made in our understanding of self-assembly such that complexes that transcend the ternary level are now viable targets in supramolecular syntheses[8] and may be used to direct the formation of covalent bonds.[8]