De Novo Design and Synthesis of Helix–Turn–Helix Structure from Short and Robust Mixed Helices Derived from C-Linked Carbo-b-Amino Acids

摘要

Peptides and proteins are molecular devices that adopt specific compact folded and organized structures for performing diverse functions in living systems. The formation of such tertiary and quaternary structures arises from the assembly of stable secondary structures such as helices, sheets, and turns. The development of nonnatural peptides[1–4] with compact and specific conformations is of considerable interest to understand the folding and stabilization and for designing new materials with specific biological functions.