Multiple Palladium-Catalyzed Reactions for the Synthesis of Analogues of the Highly Potent Insecticide Spinosyn A

摘要

The natural product class of spinosyns comprises a group ofmore than 20 structurally related compounds that have been isolated from culture broths of the bacterium Saccharopolyspora spinosa.[1,2] These include spinosyn A (1) and D( 2),which are used world-wide in agriculture as extremely potent and highly selective insecticides[3] under the name Spinosad.[4] The spinosyns attack the neuronal activity of insects by a novel mechanism; interaction with the g-aminobutyric acid-(GABA) receptor plays a role, but it is the nicotinergic acetylcholine receptors (n-AchR) that are mainly affected.