Regiospecific C-H Bond Activation: Reversible H/D Exchange Promoted by Cu~I Complexes with Triazamacrocyclic Ligands

摘要

Selective C-H bond activation by metals under mild conditions is a major subject of research targeting the final functionalization of organic substrates.The characterization of the usually unstable intermediates of the C-H bond activation prior to functionalization is crucial for the mechanistic comprehension of the reaction.Different mechanisms,such as oxidative addition,electrophilic metalation,or agostic bonding,have been proposed in extensive work published on the C-H activation of aromatic or aliphatic compounds catalyzed by second- and third-row transition metals (TMs; i.e..Pd and Pt,and Ru,Rh,and Ir).