Short Synthesis of Skeletally and Stereochemically Diverse Small Molecules by Coupling Petasis Condensation Reactions to Cyclization Reactions

摘要

Herein, we report a short and efficient synthetic pathway that uses intramolecular cyclization reactions of readily synthesized and densely functionalized amino alcohols. The research illustrates the implementation of a strategy that enables the synthesis, in only three to five steps, of a diverse collection of single-isomer small molecules whose members have over 15 different types of skeleton. In the future, this research should also enable the consequences of the unique structural features of the compounds in small-molecule screens to be determined.[1], [2]