Enhanced Signals and Fast Nucleic Acid Hybridization By Microfluidic Chaotic Mixing

摘要

Nucleic acid hybridization techniques are widely used in both fundamental and clinical research to identify genes and mutants,to map their correlations,and to analyze their expression.DNA microarrays immobilize thousands of oli-gonucleotides,cDNA(c = complementary)clones,or poly-merase-chain-reaction(PCR)products on the solid substrate,thus providing a powerful tool for the large-scale detection of target genes.