Enantioselective Modular Synthesis of 2,4-Disubstituted Cyclopentenones by Iridium-Catalyzed Allylic Alkylation

摘要

Cyclopentenones are important structural motifs of natural products and Pharmaceuticals.Their stereoselective synthesis remains a challenge because of the numerous possible substitution patterns.Here we report a new enantioselective method for the synthesis of 2,4-disubstituted Cyclopentenones and its application in the synthesis of some interesting targets.