Chemo- and Regioselective Preparation and Reaction of a Kinetic Zinc Enolate Formed from a Thiol Ester and Bis(iodozincio)methane

摘要

Bis(iodozincio)methane (1), which has a methylene carbon atom with two nucleophilic sites, has been used for a variety of molecular transformations in which C-C bond formation isrepeated at the same carbon atom.[1, 2] In other words, it functions as a zinciomethylation reagent. Such zinciomethy lation of acylating reagents should afford the kinetic enolatesof ketones. Many functional groups should be tolerated during the transformation because of the modest reactivity of organozinc compounds.